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Updated on May 3, 2009


Grey's Anatomy airs on Thursdays at 9 p.m. The series was renewed for a sixth season.

Episode 5.22: What a Difference a Day Makes (fka "Beautiful Day") (100th episode)
Airdate: May 7, 2009

* 04/23 - [Will Jeffrey Dean Morgan be appearing in Grey's Anatomy's 100th episode?] Exhibit A: Morgan appeared in the 100th ep photo-op, which took place on the Grey's set during filming of the said 100th episode. Exhibit B: The official logline for the landmark ep says, "Izzie fears the worst when she begins experiencing familiar symptoms." Source: The Ausiello Files
* 04/22 - As Meredith, Derek and all of their friends prepare for the big wedding, a group of college students, injured in a car crash as they were heading to their graduation ceremony, is admitted to the ER. Meanwhile, Izzie fears the worst when she begins experiencing familiar symptoms. Source: ABC
* 04/17 - [From an email sent to Kristin:] "One of my coworkers was in Los Angeles on business, and when I called her and told her about Grey's filming the wedding scene, she freaked and found the set. She was there for the lunch break (she said there were two or three paps there too) but she said later Katherine Heigl was standing in the doorway with T.R. Knight , and she was smoking in a wedding dress. She had a big jacket/robe thing over it, but she said there was no doubt it was a wedding dress. She said Katherine was only in the doorway a minute or two before they called her back in, but she has no doubt that it was a wedding dress." Source: Kristin on E!Online
* 04/13 - And as reported by Shonda Rhimes herself, Derek and Mer are supposed to be getting married in the upcoming 100th episode, and Izzie's dying wish is to give them the wedding she may or may not be able to ever have herself. Source: Kristin on E!Online
* 04/13 - Via his Twitter account, Ausiello gave two clues regarding the wedding: It's not **e* and ***s***a. It's not *** C***f and A***e. Source: Ausiello's Twitter Account [Note: The first clue seems to be "It's not Owen and Cristina. As for the second one, it may be "It's not the Chief and Adele.]
* 04/05 - The wedding taking place in the 100th episode on May 7? It's not Mer-Der after all! Source: The Ausiello Files
* 04/05 - At a party marking the filming of Grey's Anatomy's 100th episode, series creator Shonda Rhimes confirmed that the milestone hour will air May 7 - and indicated that it might feature the nuptials of the show's central couple. "The only thing I'll tell you about the 100th episode is that it takes place on Meredith and Derek's wedding day," Rhimes told the Associated Press at the show's celebration. "That's big," Rhimes underscored, "and that's all I'm going to say." Of course, were one to be hyper-analytical and parse words, it's not for certain that the Mer-Der wedding goes without a hitch. For one, it would represent a mighty short engagement (he will have only non-proposed six weeks prior). Secondly, this is Meredith and Derek we are talking about. Thirdly and perhaps most importantly, Rhimes has previously said that the wedding taking place toward season's end would be a "surprise." Now, is that "surprise" as in the aforementioned short engagement or "surprise" as in the couple that emerges at the end of the aisle is not the same one that started down it? Source: TV Guide Online
* 04/05 - Over at Grey's, series creator Shonda Rhimes has already confirmed that one of the show's couples will tie the knot later this season, and there's increasingly loud buzz that the event will take place on May 7, during the show's landmark 100th episode, appropriately titled "Beautiful Day." Adding to the speculation: The episode will feature a minister. Source: The Ausiello Files
* 02/08 - Nathan, a male intern is eager to impress the doctors. He brags about doing a chest tube correctly on his first try. Later, he is upset because he thinks he may have killed a baby during a procedure. A female doctor will reassure him that the baby will be fine. Source: SpoilerFix.com
* 11/20/2008 - Nathan: Male intern, mid 20's, Bi-racial (African American & Caucasian). He is smart and funny; a boy next door type. Recurring Guest Star. Source: SpoilerTV





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General Spoilers:
* 04/22 - Owen doesn't have time for Cristina anymore (what with his newfound interest in turning George into a trauma surgeon). Actually, to be more specific, Owen's therapist doesn't let Owen have time for her. Yep, Owen's shrink has given him a specific list of three-word sentences he can say to Yang, but "I love you" is definitely not one of them. Either way, Cristina is not a happy camper. Source: Kristin on E!Online
* 04/05 - [Cristina and Owen] are far from over. As Kevin McKidd himself told EW's Jennifer Armstrong, the exes will be thrown "a huge curveball that neither of them see coming. Just as he starts to get over his thing, something else happens. Which is good and bad. It's like, 'Oh my God, this is big.' It will be interesting to see how it leads into next season." Source: The Ausiello Files
* 02/27 - The show may be giving Meredith another long-lost sibling -- this one a byproduct of her mother's affair with the Chief. Source: The Ausiello Files
* 02/23 - The latest Grey's Anatomy rumor making the rounds has Shonda Rhimes mulling a bait and switch that would find terminally ill Izzie living and George dying. Source: The Ausiello Files
* 02/12 - According to inside sources who work on Grey's, it is likely that Heigl and Knight will make an exit at the end of the current season. Both have asked to leave the show. However, ABC
needs to sign off on letting them out of their contracts, which has not been done. Source: Kristin on E!Online


* new 02/02 - [Bailey] receives some potentially career-altering news. [...] Lots of cheesy, slow-mo, piano-scored interludes will give way to an emotional collapse [between Cristina and Owen] that is either extremely moving or ridiculously over the top. Source: The Ausiello Files
* 01/25 - [Denny]'ll be around at least through March, since that's when Izzie's aneurysm-esque medical condition finally gets diagnosed. [...] Sources confirm [that Faye Dunaway] has signed on for at least one episode of Grey's Anatomy to air in February. She'll play a renowned doc at the hospital who crosses paths with the Chief, Cristina and Owen. Source: The Ausiello Files
* 12/12/2008 - New details are emerging about Jennifer Westfeldt's forthcoming arc as a patient on Grey's Anatomy. Or, I should say, new detail : She's married to Angels in America's Ben Shenkman. [...] He's not dropping by Seattle Grace to keep vigil at his ailing wife's bedside. According to a Grey's insider, he's a patient, too -- and a critical one at that. Like Westfeldt, Shenkman is signed on for multiple episodes. [...] [Eric Stoltz's serial killer character] is there to receive medical attention after he suffers a major beat down in prison. [T.R. Knight, who plays George, is in talks to be released from the show.] Source: The Ausiello Files
* 12/04/2008 - Izzie's hallucinations are health-related -- and brain-related. And although the specific name of the ailment is being kept in the safe underneath Rhimes' desk, I'm told it's similar to an aneurysm. And every time it flares up, she sees Denny. Source: The Ausiello Files
* 12/04/2008 - A source close to the show tells me, "The reason [the actor] has not been on is because [he or she] has been a pain in the ass lately, trying to change scenes and dialogue, being hard to work with and putting up an attitude. The higher-ups were getting tired of it, so they tweaked [him or her] out of some episodes. That's why you haven't really seen [him or her] lately." A second source seconds that emotion: "[He or she] is not really getting along too well with producers right now." Source: Kristin on E!Online
* 11/26/2008 - Jennifer Westfeldt is joining Grey's Anatomy for a multi-episode arc. [... She] is coming on as a patient. [... The crossover will] take place over the course of three episodes (Feb. 5, 12, and 19) and the only confirmed participant as of now is Kate Walsh. [...] Denny will be haunting Izzie at least through February. Source: The Ausiello Files
* 11/20/2008 - "I think the love triangle with Denny, Izzie, and Alex is among the most interesting we've ever done. Watching the chemistry between Jeffrey and Katherine again has been really touching. I can't wait for our viewers to see where we're taking it. But what it won't involve is Izzie having a brain tumor," [Shonda Rhimes revealed... Denny will] be in at least five episodes. Source: The Ausiello Files
* 11/08/2008 - Sources tell TVGuide.com exclusively that ABC powerhouse Grey's Anatomy and its spin-off, Private Practice, will be embarking on a multi-episode crossover story come February sweeps. Though at this very early stage the number of episodes and the sum total of actors involved has yet to be nailed down, it can at least be confirmed that Kate Walsh's Dr. Addison Montgomery will again be walking the halls of Seattle Grace, as she did for one episode last spring (several months after Private Practice made its debut). Source: TV Guide Online
* 11/06/2008 - A female patient named Natalie wants to leave the hospital because she'll get fired from her job at a bar if she misses any more shifts. As the doctor taking care of her fixes a bandage before she goes, he notices that Natalie has many scars. Natalie also tells the male doctor that she's been flirting with him all day and that he should have reciprocated. Source: SpoilerFix.com [Note: This was set to occur around episode 9. It's unknown if it's been pushed to another episode or dropped.]
* 11/04 /2008- [The show] is now casting "star names only" for a "former military nurse who is maternal." Cristina most definitely has a "Major" romance coming on! Source: Kristin on E!Online
* 11/02/2008 - Jessica Capshaw (The L Word, The Practice) will play Dr. Arizona Robbins, a pediatrician who's called in to consult on a case and winds up butting heads with Bailey. I hear that Capshaw has signed on for at least three episodes, though that could lead to more, and that she will make her first appearance midway through the season. Source: LA Times
* 08/28/2008 - [Dr. Addison Montgomery] may take another trip back to Seattle Grace sometime in the middle of the season, hints executive producer Shonda Rhimes. "I don't know if it's going to work with the story, and we don't want her to come back for a visit if it doesn't feel important, something only Addison can do," says Rhimes. "But the idea is on the table." Source: Entertainment Weekly
Edited by oncetherewasaway, Jul 14 2009, 04:54 PM.
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